| Coaches | |
|---|---|
| Position | Name |
| Head Coach | Sean McDermott |
| Offensive Coordinator | Joe Brady |
| Defensive Coordinator | Bobby Babich |
| Special Teams Coach | Matthew Smiley |
| Offense | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | NO | Player 4 | NO | Player 5 |
| FB | 41 | Reggie Gilliam | ||||||||
| QB | 17 | Josh Allen | 11 | Mitchell Trubisky | 6 | Shane Buechele | ||||
| RB | 4 | James Cook | 22 | Ray Davis | 26 | Ty Johnson | 37 | Darrynton Evans | NA | Frank Gore Jr.(R) |
| TE | 86 | Dalton Kincaid | 88 | Dawson Knox | 85 | Quintin Morris | 83 | Tre' McKitty | 84 | Zach Davidson |
| WR | 10 | Khalil Shakir | NA | Keon Coleman | 1 | Curtis Samuel | 14 | Chase Claypool | 13 | Mack Hollins |
| Defense | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | NO | Player 4 | NO | Player 5 |
| FS | 21 | Mike Edwards | 39 | Cam Lewis | 3 | Damar Hamlin | ||||
| LCB | 31 | Rasul Douglas | 5 | Kaiir Elam | 32 | Kyron Brown | ||||
| LDE | 50 | Greg Rousseau | 99 | Casey Toohill | 56 | Javon Solomon | 96 | Kameron Cline | ||
| LDT | 92 | DaQuan Jones | 90 | DeWayne Carter | 98 | Austin Johnson | 51 | Eli Ankou | ||
| MLB | 43 | Terrel Bernard | 54 | Baylon Spector | ||||||
| RCB | 47 | Christian Benford | 7 | Taron Johnson | 25 | Daequan Hardy | 46 | Ja'Marcus Ingram | ||
| RDE | 40 | Von Miller | 57 | A.J. Epenesa | 94 | Dawuane Smoot | 59 | Kingsley Jonathan | ||
| RDT | 91 | Ed Oliver | 93 | DeShawn Williams | ||||||
| SLB | 52 | Nicholas Morrow | 42 | Dorian Williams | ||||||
| SS | 9 | Taylor Rapp | 24 | Cole Bishop | 36 | Kendall Williamson | ||||
| WLB | 58 | Matt Milano | 45 | Deion Jones | 48 | Edefuan Ulofoshio | ||||
| Special Teams | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | ||||
| K | 2 | Tyler Bass | ||||||||
| KR | 10 | Khalil Shakir | 87 | Andy Isabella | ||||||
| P | 8 | Sam Martin | 15 | Matt Haack | ||||||
| PR | 10 | Khalil Shakir | NA | Keon Coleman | 25 | Daequan Hardy | ||||
